The injured teens were part of a group who requested a local ride-share service about 3am on Sunday, police said.

However, when the group got inside the van the driver, who was allegedly under the influence of alcohol, began driving erratically, causing them to be thrown around inside.

An "altercation took place between the passengers," a police spokesperson said on Sunday. "All the information says that his driving was erratic and that might have lead to the altercation."

The spokesperson said it was not believed the driver was known to the group.

After the altercation, the driver dropped the group of teens on Budgewoi Road, Noraville but when he drove off he allegedly did a u-turn and drove straight for the group, hitting two of them, police said.

"It as alleged he turned around and went back and drove towards the young people and in doing so he collided with two of those young people," the spokesperson said.

A 15-year-old boy was left with pelvis, leg and back injuries and was taken to John Hunter Hospital in a serious but stable condition.

A 16-year-old girl was treated by paramedics for significant head injuries.

She was transferred to Wyong Hospital in a serious condition before being transferred to Royal North Shore Hospital.

After the collision, the teens are alleged to have dragged the man from his van and assaulted him; he was taken to Wyong Hospital with minor head injuries under police guard where he underwent mandatory blood and alcohol tests.

The man was released from hospital on Sunday afternoon.

He was was charged with multiple offences including dangerous driving occasioning grievous bodily harm, negligent driving occasioning grievous bodily harm, driving whilst suspended, and take and drive conveyance without consent of owner.

He was refused bail and is due to appear before Wyong Local Court on Monday.