The property at 65 Squire Close in Pokolbin, known as Block Eight, offers a cosy farmhouse and five beautifully appointed accommodation villas set among a boutique vineyard, olive grove and lakes.

It it being marketed by Cain Beckett, of Jurd's Real Estate, through expressions of interest with a guide of $4.5 million. He said Sydneysiders recognised "a lot of value for your money" in the lifestyle property which comes with an income stream.

Todd Alexander, the author of Thirty Thousand Bottles of Wine and a Pig Called Helga, and his partner Jeff Ross bought the 100-acre property in 2012.

They have totally transformed it from a run-down vineyard to one of the Hunter Valley's most popular and prestigious boutique accommodation retreats, complete with award-winning wines made by the Hunter's Daniel Binet.

The book struck a particular chord with readers who bonded over the pair's journey from corporate Sydney life - Mr Alexander is a former eBay executive - to an idyllic property with grapes and olives and the aucthor's dream of becoming the Hunter version of Maggie Beer.

She loved the story, saying "never before have I felt the responsibility for someone's tree-change" and the book "made me laugh out loud."

"I never put this in the book, but we had a 10-year goal to open the Hunter Valley's most beautiful accommodation," Mr Alexander said.

"We feel like we have achieved that now and want to give someone else the opportunity to fall in love with it. I think our property is also one of the best places to live in the world. We have given it every ounce of love we have."

Mr Beckett described it "one of the best properties" he had listed and did not expect it to last long.

"COVID-19 has inspired thousands of tree-changers and the Hunter Valley market is very strong," Mr Beckett said.