Award-winning journalist and Pink Meets Teal founder Jill Emberson passed away overnight.
A statement from her daughter Malia and husband Dr Ken Lambert said Ms Emberson died peacefully surrounded by loved ones who were holding her hands in her "final moments".
"Jill was a fearless campaigner for ovarian cancer, a brilliant journalist; broadcaster; beloved wife, fierce mother; friend to many. She worked tirelessly all her life to call out injustice; make the world a better place," her family said.
"Jill put ovarian cancer firmly in the mind of Australians and her successful advocacy will save the lives of countless women in the future. She started the social movement Pink Meets Teal which lobbies for cancer funding fairness.
"Jill was an inspiration to everyone who knew her, and her love; care for her dearest was extraordinary . We've all cried bucketloads of tears; don't know when we will stop."
The statement said the details of a memorial service for Ms Emberson would be shared in coming days.
The former ABC radio presenter in Newcastle founded the Pink Meets Teal campaign, after she was diagnosed with advanced ovarian cancer in February 2016.
A petition she created calling on parity of funding for research between Breast Cancer and Ovarian Cancer has been signed by 40,000 people.
Her award-winning podcast Still Jill shared experiences of her cancer journey.
The director of Ovarian Cancer Australia Josy Shaw told the ABC Ms Emberson had been "quite possibly the greatest impact we've ever seen at Ovarian Cancer Australia".
"The effect she's had on the sector financially has never been seen before," she said.
Ms Emberson addressed the International Women's Day morning tea held at the Civic Theatre in March.
She told the audience she refused to "die quietly".
"It's not in my nature," she said.
Jill Emberson International Women's Day Address
"I think we need to get angry about this disease, as angry as women were back in the 1970s about breast cancer," she said.
"We need to get angry that our reproductive organs, our ovaries, the very cradle of life, are not getting the funding they need to stop women dying of cancer.
"It's as simple as that: money, research, better outcomes.
"Let's do it for our vaginas, our vulvas, our ovaries, because those women with those cancers are dying at an absolutely unacceptable rate," she said.
"And I meet them up at the John - they're awkward, they're embarrassed, they're sad, they're horrified. They know that their chances of living a life they've always dreamed of are really going to be limited.
"Those women who die leave behind huge, unmet potential."
More to come.