A man and a woman are at John Hunter Hospital in a stable condition following a car and truck crash on the Pacific Highway at Hexham.
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At about 12.45pm on Thursday, NSW Ambulance responded to reports of the incident, sending six crews to the scene.
Paramedics treated a 63-year-old woman passenger for spinal, abdominal, pelvic and leg injuries, and a 66-year-old man for a fractured ankle and abdominal injuries.
The woman was transported to John Hunter Hospital by road in a serious but stable condition, with an aeromedical team meeting the crew on route to the hospital.
The man was also taken to John Hunter Hospital by road in a stable condition.
NSW Ambulance duty operations manager Inspector Joel De'Zuna said it was "a horrendous accident for everyone involved".
"When responding to any motor vehicle accident, particularly when a car and a truck is involved, you are never really sure how extensive the injuries are going to be," he said.
"Paramedics did a great job responding to the scene and treating the patients efficiently.
"This is a timely reminder for all road users to be vigilant, particularly when driving in wet weather conditions."
