Two person were taken to John Hunter Hospital after the major multi-vehicle crash on the New England Highway on Thursday morning. Fire and Rescue NSW worked to free the male driver of a truck and his dog, who were trapped in the wreckage.

The New England Highway is closed in both directions between Hexham Bridge and Anderson Drive.

Ambulance NSW said six people were assessed by paramedics after the crash, which happened before 6.30.

"Paramedics were confronted with a complex scene on arrival," NSW Ambulance Inspector Jason Saper said.

"One patient was initially trapped, with the assistance of other emergency services we were able to safely extricate the patient and provide ongoing treatment.

"Paramedics did an excellent job treating multiple patients on a very busy road. We encourage motorists to drive with caution especially in peak times."

Motorists have been advised to void the area and allow plenty of extra travel time.

Northbound motorists heading towards Hexham can use M1 Pacific Motorway, Newcastle Link Road, Newcastle Inner City Bypass and Maitland Road, however traffic is extremely heavy.

Northbound motorists heading to Raymond Terrace and beyond can use the M1, Weakleys Drive, Glenwood Drive, Thornton Road/Railway Avenue/Edwards Avenue/Government Road, Raymond Terrace Road, William Bailey Street and Adelaide Street to join the Pacific Highway.

Southbound/westbound should consider using Maitland Road, Newcastle Inner City Bypass, Newcastle Link Road and the M1 Pacific Motorway to travel between Hexham and Newcastle Interchange/Beresfield.

Traffic is also heavy in both directions on the Hunter Expressway/Newcastle Link Road at the M1 Pacific Motorway. Exercise caution and allow plenty of extra travel time.

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